Cronología de la esclerosis tuberosa

La TSC es una enfermedad genética rara y multisistémica que puede causar el crecimiento de tumores benignos en el cerebro u otros órganos vitales como los riñones, el corazón, los ojos, los pulmones y la piel.

La historia de la investigación sobre la TSC se divide comúnmente en cuatro períodos.

[2]​ A finales del siglo XIX, médicos notables que trabajaban en hospitales de enseñanza europeos describieron por primera vez las manifestaciones corticales y dermatológicas; estos primeros investigadores han sido reconocidos con epónimos como «enfermedad de Bourneville»[3]​ y «adenoma sebáceo de Pringle».

Finalmente, a principios del siglo XXI, comenzó a desarrollarse una comprensión molecular de la enfermedad, junto con posibles tratamientos terapéuticos no quirúrgicos.

2012 Se llevó a cabo una conferencia de consenso y se publicaron directrices revisadas para el diagnóstico y manejo de la esclerosis tuberosa.

Head and shoulders of a middle-aged man wearing a coat, facing his right. His receding hair is swept back and his beard is unruly, obscuring his mouth and chin.
Désiré-Magloire Bourneville describió por primera vez la enfermedad en 1880, denominándola «esclerosis tuberosa de las circunvoluciones cerebrales».
A sketch consisting only of the face and shirt collar. Across the nose, the cheeks adjacent to the nose and mouth, and the chin are numerous red pimples. Above are the words "1. Végétations vasculaires."
Vegétations vasculaires por Rayer.
A side profile sketch of a brain, with parts indicated by a letter code. The normal convolutions of the brain are distorted in these areas, forming lumps or thickened folds.
Esclerosis tuberosa cerebral que muestra circunvoluciones escleróticas e hipertróficas.
Head and shoulders of a young lady wearing a blouse, looking slightly to her right. Her light brown hair is tied up. Her face is covered in red pimples, particularly the cheeks around her nose, the fleshy part of her nose, and her chin.
Mujer con adenoma sebáceo, 1900.
The fine blood vescles seen at the back of the eye are drawn in red and dark blue on an sandy-coloured background. There are four white blobs of various sizes, one behind and one in front of the blood vescles.
Fakoma de retina de Jan van der Hoeve.
Menor con TS («epiloia»), 1926
An slice through the head, showing the cerebellum, a small portion of each temporal lobe, the ears, the orbits, and the sinuses. Bone appears white on the black background; brain, eyeballs and ears are grey.
TC craneal normal.
A brightly coloured blob, roughly the shape of the head sliced horizontally, on a dark blue background. Within the head is a symmetrical pattern of blobs, having the false-colours of dark blue, cyan, green, yellow and red to indicate increasing brain activity.
TEP craneal normal.
A 3D skeleton of the molecular structure consisting of over around fifty small grey spheres representing carbon, linked by grey tubes. Attached to these are white spheres representing hydrogen. There are a handful of red spheres representing oxygen, and one blue sphere, which is nitrogen.
Rapamicina (sirolimus)