Buscando una alternativa que integrara sus intereses decide entrar a estudiar Ingeniería en el año 1967 en la Universidad de Chile.
Mientras cursaba su doctorado, trabajó con dos científicos considerados fundadores de la biotecnología a nivel mundial, Peter Dunnill y Malcolm Lilly.
En 1986, Juan Asenjo comienza a colaborar con un antiguo colega (Leo Pyle, con quien había trabajado en su tesis), creando y organizando el área de Ingeniería Bioquímica del Imperial College of London, en Reino Unido.
Además, en muchas partes del mundo se lava a bajas temperaturas, por lo que nuestro desarrollo permite hacerlo en forma más eficiente”.
(1990) PEG activation and ligand binding for the affinity partitioning of proteins in aqueous two-phase systems.
(1990) The Rational Design of Large Scale Protein Separation Process, in Separations for Biotechnology II, Ed.
(1990) Differential Product Release from Yeast Cells By Selective Enzymatic Lysis, in Separations for Biotechnology II, Ed.
(1993) Selective release of recombinant protein particles (VLPs) from yeast using a pure lytic glucanase enzyme.
Mathematical Modelling and Computer Simulation of Continuous Aqueous Two-phase Extraction,in: Separations for Biotechnology 3, Ed.
(1995) Factors affecting the esterification of lauric acid using an immobilized biocatalyst: enzyme characterization and studies in a well-mixed reactor.
and Asenjo J.A., (2003) Study of recombinant microorganism populations characterized by their plasmid content per cell using a segregated model.
and Asenjo J.A., (2004) A mixed mechanistic-electrostatic model to explain pH dependence of glycosyl hydrolase enzyme activity.
Salgado, C., Rapaport, I. and Asenjo, J.A., (2005) Is it possible to predict the average surface hydrophobicity of a protein using only its amino acid composition?
Parra L., Reyes F., Acevedo J.P., Salazar O., Andrews B., Asenjo J., (2008) Cloning and fusion expression of a cold-active lipase from marine Antarctic origin.
(2010) Metabolic Flux Analysis of Embryonic Stem Cells Using Three Distinct Differentiation Protocols and Comparison to Gene Expression Patterns.
(2011) Mutagénesis Objective Search and Selection Tool (MOSST): an algorithm to predict structure-function related mutations in proteins.
Rateb, M.E., Houssen, W.E., Arnold, M., Abdelrahman, M.H., Deng, H., Harrison, W.T.A., Okoro, Ch.K., Asenjo, J.A., Andrews, B.A., Ferguson, G., Bull, A.T., Goodfellow, M., Ebel, R. and Jaspars, M. (2011) Chaxamycins A-D, Bioactive Ansamycins from a Hyper-arid Desert Streptomyces sp.
Nachtigall, J., Kulik, A., Helaly, S., Bull, A., Goodfellow, M., Asenjo, J.A., Maier, M., Wiese, J., Imhoff, J.F., Süssmuth, R. D. and Fiedler, H-P. (2011) Atacamycins A-C, 22-membered antitumor macrolactones produced by Streptomyces sp C38*, The Journal of Antibiotics, 64, 775-780.
and Eisen, T. (2014) An integrated computational approach can classify VHL missense mutations according to risk of clear cell Renal carcinoma.
(2015), Analyzing redox balance in a synthetic yeast platform to improve utilization of brown macroalgae as feedstock.
(2016) MILP reformulations for the design of biotechnological multi-product batch plants using continuous equipment sizes and discrete host selection.
(2016) Acidithiobacillus ferrooxidands’s comprehensive model driven analysis of the electron transfer metabolism and synthetic strain design for biomining applications.
Nov., isolated from a high altitude Atacama Desert soil and emended description of Streptomyces noboritoensis Isono et al.
(2017) One-Step Combined focused epPCR and Saturation Mutagenesis for Thermostability Evolution of a New Cold-Active Xylanase.
Nov., an actinobacterium from a very high altitude Cerro Chajnantor gravel soil in northern Chile.
(2018) AAV gene therapy for alcoholism: Inhibition of mitochondrial Aldehyde dehydrogenase enzyme expression in Hepatoma cells.
(2018), Metabolic modelling and flux analysis of microorganisms from the Atacama Desert used in biotechnological processes.
Castro, J.F., Nouioui, I., Sangal, V., Choi, S., Yang, S.J., Kim, B.Y., Trujillo, M., Riesco, R., Montero-Calasanz, M.C., Rahmani, T.P.D., Bull, A.T., Sutcliffe, I.C., Asenjo, J.A., Andrews, B.A., Goodfellow, M. (2018) Blastococcus atacamensis sp.
(2019) Heterologous expression and biochemical characterization of a novel cold-active α-amylase from the Antarctic bacteria Pseudoalteromonas sp.
nov., an alkalitolerant species isolated from Chilean Altiplano soil, and emended description of Streptomyces chryseus (Krasil’nikov et al.