Chemicals that inhibit the use of a metabolite
Pyrimidine analogues are antimetabolites which mimic the structure of metabolic pyrimidines.
Examples
Medical uses
Pyrimidine antimetabolites are commonly used to treat cancer by interfering with DNA replication.[1]
References
- ^ Parker, William B. (2009). "Enzymology of Purine and Pyrimidine Antimetabolites Used in the Treatment of Cancer". Chem Rev. 109 (7): 2880–2893. doi:10.1021/cr900028p. PMC 2827868. PMID 19476376.