La Serie Mundial de 1921 fue disputada entre New York Giants y New York Yankees.
[1][2][3] Los Giants resultaron ganadores al vencer en la serie por 5 partidos a 3.
LG: Carl Mays (1–0) LP: Phil Douglas (0–1) LG: Waite Hoyt (1–0) LP: Art Nehf (0–1) LG: Jesse Barnes (1–0) LP: Jack Quinn (0–1) LG: Phil Douglas (1–1) LP: Carl Mays (1–1) HRs: NYY – Babe Ruth (1) LG: Waite Hoyt (2–0) LP: Art Nehf (0–2) LG: Jesse Barnes (2–0) LP: Bob Shawkey (0–1) HRs: NYG – Irish Meusel (1), Frank Snyder (1) NYY – Chick Fewster (1) LG: Phil Douglas (2–1) LP: Carl Mays (1–2) LG: Art Nehf (1–2) LP: Waite Hoyt (2–1)