[1]​ Según el censo de 2000[2]​, el condado cuenta con 381.751 habitantes, 148.219 hogares y 105.531 familias residentes.

Hay 156.720 unidades habitacionales con una densidad promedio de 67 u.a./km² (173 u.a./mi²).

De los 148.219 hogares, en el 32,50% de ellos viven menores de edad, 58,30% están formados por parejas casadas que viven juntas, 9,00% son llevados por una mujer sin esposo presente y 28,80% no son familias.

Por cada 100 mujeres hay 96,70 hombres y por cada 100 mujeres de más de 18 años hay 93,80 hombres.

York Cross Roads | Dallastown | Delta | Dillsburg | Dover | East Prospect | Fawn Grove | Felton | Franklintown | Glen Rock | Goldsboro | Hallam | Hanover | Jacobus | Jefferson | Lewisberry | Loganville | Manchester | Mount Wolf | New Freedom | New Salem | North York | Railroad | Red Lion | Seven Valleys | Shrewsbury | Spring Grove | Stewartstown | Wellsville | West York | Windsor | Winterstown | Wrightsville | Yoe | York Haven | Yorkana Carroll | Chanceford | Codorus | Conewago | East Hopewell | East Manchester | Fairview | Fawn | Franklin | Heidelberg | Hellam | Hopewell | Jackson | Lower Chanceford | Lower Windsor | Manchester | Manheim | Monaghan | Newberry | North Codorus | North Hopewell | Paradise | Peach Bottom | Penn | Shrewsbury | Spring Garden | Springettsbury | Springfield | Warrington | Washington | West Manchester | West Manheim | Windsor | York East York | Emigsville | Grantley | Parkville | Pennville | Shiloh | Springetts Manor-Yorklyn | Spry | Stonybrook | Stonybrook-Wilshire | Susquehanna Trails | Tyler Run | Tyler Run-Queens Gate (histórico) | Valley Green | Valley View | Weigelstown Accomac | Admire | Airville | Ambau | Bermudian‡ | Big Mount | Brogue | Bryansville | Cly | Craley | Detters Mill | Foustown | Gatchellville | Glades | Glenville | Gnatstown | Hametown | Hanover Junction | Hopewell Center | Kralltown | Leaders Heights | Mackey Ford | Mount Royal | New Bridgeville | New Market | New Park | Porters Sideling | Stoverstown | Sunnyburn | Tolna | Thomasville | Violet Hill | Woodbine