In terms of the normal mechanism of T cell we find that it is a type of white blood cell that has an important role in immunity, and is made from thymocytes.[5] One sees in the partial disorder of T cells that happen due to cell signaling defects, are usually caused by hypomorphic gene defects.[6] Generally, (micro)deletion of 22Q11.2 is the most often seen.[7]
In the U.S. this defect occurs in about 1 in 70,000, with the majority of cases presenting in early life.[1]Furthermore, SCID has an incidence of approximately 1 in 66,000 in California.[10]
^ a b c d e f g h i j k lMedscape > T-cell Disorders Archived 2019-12-30 at the Wayback Machine. Author: Robert A Schwartz, MD, MPH; Chief Editor: Harumi Jyonouchi, MD. Updated: May 16, 2011
^ a b c"Immunodeficiency (Primary and Secondary). Information". patient.info. Archived from the original on 2022-12-21. Retrieved 2017-05-18.
^ a bFried, Ari J.; Bonilla, Francisco A. (2017-05-19). "Pathogenesis, Diagnosis, and Management of Primary Antibody Deficiencies and Infections". Clinical Microbiology Reviews. 22 (3): 396–414. doi:10.1128/CMR.00001-09. ISSN 0893-8512. PMC 2708392. PMID 19597006.
^ a b"T-cell count: MedlinePlus Medical Encyclopedia". medlineplus.gov. Archived from the original on 2019-12-01. Retrieved 2017-05-18.
^Alberts B, Johnson A, Lewis J, Raff M, Roberts k, Walter P (2002) Molecular Biology of the Cell Archived 2010-11-12 at the Wayback Machine. Garland Science: New York, NY pg 1367
^Cole, Theresa S.; Cant, Andrew J. (2010). "Clinical experience in T cell deficient patients". Allergy, Asthma & Clinical Immunology. 6 (1): 9. doi:10.1186/1710-1492-6-9. ISSN 1710-1492. PMC 2877019. PMID 20465788.
^Prasad, Paritosh (2013). Pocket Pediatrics: The Massachusetts General Hospital for Children Handbook of Pediatrics. Lippincott Williams & Wilkins. p. Google books gives no page. ISBN 9781469830094. Archived from the original on 7 April 2022. Retrieved 19 May 2017.
^ a bPage 435 Archived 2023-01-12 at the Wayback Machine in: Jones, Jane; Bannister, Barbara A.; Gillespie, Stephen H. (2006). Infection: Microbiology and Management. Wiley-Blackwell. ISBN 978-1-4051-2665-6.
^ a b c d e f g h i j k lPage 432 Archived 2023-01-12 at the Wayback Machine, Chapter 22, Table 22.1 in: Jones, Jane; Bannister, Barbara A.; Gillespie, Stephen H. (2006). Infection: Microbiology and Management. Wiley-Blackwell. ISBN 978-1-4051-2665-6.
^"B-Cell and T-Cell Combined Disorders: Background, Pathophysiology, Epidemiology". 2018-12-11. Archived from the original on 2019-04-14. Retrieved 2017-05-19. {{cite journal}}: Cite journal requires |journal= (help)
Further reading
Verbsky, James W.; Chatila, Talal A. (2017-05-12). "T Regulatory Cells in Primary Immune Deficiencies". Current Opinion in Allergy and Clinical Immunology. 11 (6): 539–544. doi:10.1097/ACI.0b013e32834cb8fa. ISSN 1528-4050. PMC 3718260. PMID 21986549.
External links
Pubmed
Scholia has a topic profile for T cell deficiency.