Elisha Otis (1811–1861), American inventor and industrialist, inventor of an elevator safety device and founder of Otis Elevator Company
Eliza Ann Otis (1833–1904), American poet, journalist, and philanthropist, co-founder, publisher and associate editor of the Los Angeles Times newspaper
Elwell Stephen Otis (1838–1909), American general who served in the Civil War, Spanish-American War and Philippine-American War
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