Troponin T (shortened TnT[1] or TropT) is a part of the troponin complex, which are proteins integral to the contraction of skeletal and heart muscles. They are expressed in skeletal and cardiac myocytes. Troponin T binds to tropomyosin and helps position it on actin,[2] and together with the rest of the troponin complex, modulates contraction of striated muscle.[3] The cardiac subtype of troponin T is especially useful in the laboratory diagnosis of heart attack because it is released into the blood-stream when damage to heart muscle occurs.[4] It was discovered by the German physician Hugo A. Katus at the University of Heidelberg, who also developed the troponin T assay.
Fast skeletal troponin T3, TNNT3 (11p15.5, 600692)
Reference values
The 99th percentile cutoff for cardiac troponin T (cTnT) is 0.01 ng/mL.[5] The reference range for the high sensitivity troponin T is a normal < 14 ng/L, borderline of 14-52 ng/L, and elevated of >52 ng/L.[6]
Background
The troponin complex is responsible for coupling the sarcomere contraction cycle to variations in intracellular calcium concentration. Increased troponin T levels after an episode of chest pain indicates myocardial infarction.[7] It was discovered by the German physician Hugo A. Katus at the University of Heidelberg. He also developed the troponin T assay.[8] In patients with non-severe asymptomatic aortic valve stenosis and no overt coronary artery disease, the increased troponin T (above 14 pg/mL) was found associated with an increased 5-year event rate of ischemic cardiac events (myocardial infarction, percutaneous coronary intervention, or coronary artery bypass surgery).[9] In patients with stable coronary artery disease, the troponin T concentration has long been found to be significantly associated with the incidence of cardiovascular death and heart failure, but it was 2014 before it began to be accepted as a predictor of who would later suffer acute myocardial infarction (heart attack).[10][11]
^ Jin, Jian-Ping (1 de enero de 2016), Jeon, Kwang W. (ed.), "Capítulo uno: evolución, regulación y función de la región variable N-terminal de la troponina T: modulación de la contractilidad muscular y más allá ", Revista Internacional de Biología Celular y Molecular , 321 , Academic Press: 1–28, doi :10.1016/bs.ircmb.2015.09.002, PMID 26811285
^ Ashvarya Mangla. "Troponinas". medscape . Consultado el 24 de julio de 2017 .Actualizado: 14 de enero de 2015
^ "Troponina T, alta sensibilidad". www.calgarylabservices.com . Consultado el 29 de agosto de 2019 .
^ Michael A. Chen. "Prueba de troponina". MedlinePlus , Biblioteca Nacional de Medicina de EE. UU . Consultado el 24 de julio de 2017 .Fecha de revisión 6/10/2015
^ "Desarrollo del inmunoensayo de troponina T cardíaca". Asociación Estadounidense de Química Clínica, Inc. 2008 . Consultado el 1 de mayo de 2010 .
^ Hadziselimović, Edina; Greve, Anders M.; Sajadieh, Ahmad; Olsen, Michael H.; Kesäniemi, Y. Antero; Nienaber, Christoph A.; Ray, Simón G.; Rossebø, Anne B.; Wachtell, Kristian; Nielsen, Olav W. (abril de 2023). "Asociación de troponina T de alta sensibilidad con resultados en estenosis aórtica asintomática no grave: un subestudio post-hoc del ensayo SEAS". eMedicina Clínica . 58 : 101875. doi : 10.1016/j.eclinm.2023.101875. ISSN 2589-5370. PMC 10006443 . PMID 36915288.
^ Omland, Torbjørn; De Lemos, James A.; Sabatine, Marc S.; Christophi, Costas A.; Arroz, Madeline Murguía; Jablonski, Kathleen A.; Tjora, Resuelve; Domanski, Michael J.; Gersh, Bernard J.; Rouleau, Jean L.; Pfeffer, Marc A.; Braunwald, Eugenio (2009). "Un ensayo de troponina T cardíaca sensible en la enfermedad de las arterias coronarias estable". Revista de Medicina de Nueva Inglaterra . 361 (26): 2538–2547. doi :10.1056/NEJMoa0805299. PMC 2997684 . PMID 19940289.
^ "Condiciones de salud: enfermedades, afecciones e información médica - MSN Health & Fitness". vidasaludable.msn.com . Consultado el 12 de abril de 2018 .[ enlace muerto permanente ]