Greenwood High School is located in the city of Greenwood, South Carolina. The school has approximately 1,600 students and is one of two high schools in Greenwood School District 50. The principal is Kathryn Benjamin. The school's mascot is the Eagle.
In the summer of 2008, Greenwood High began renovations to the campus. A new classroom wing was added, which has been completed and is now known as the "H-Building", and the library was extended. The school has a new office section and has added in a new press box and fixed up the home bleachers.
In the summer of 2020 the Greenwood Performing Arts Auditorium was completed on Greenwood High School’s campus.
Greenwood High School competes in SCHSL Class AAAA Region I with teams in baseball, basketball, cross country, football, golf, soccer, softball, swimming, tennis, track, volleyball, and wrestling.