Buffalo Junction is an unincorporated community in Mecklenburg County, Virginia, United States. Buffalo Junction is located on Virginia State Route 49 4.4 miles (7.1 km) west-southwest of Clarksville. Buffalo Junction has a post office with ZIP code 24529.[2][3]
The name of the location is derived from its history as a railroad junction. The Atlantic and Danville Railway used to pass through the community and a wye was located there that connected the mainline to Buffalo Springs, 3.89 miles away, via the Buffalo Springs Branch. The branch opened prior to 1890 and was closed by 1940.