β-Propiolactone, often simply called propiolactone, is an organic compound with the formula CH2CH2CO2. It is a lactone family, with a four-membered ring. It is a colorless liquid with a slightly sweet odor, highly soluble in water and organic solvents.[2][3] The carcinogenicity of this compound has limited its commercial applications.[4]
In the research laboratory, propiolactones have been produced by the carbonylation of epoxides.[6]
Reactions and applications
It reacts with many nucleophiles in a ring-opening reactions. With water hydrolysis occurs to produce 3-hydroxypropionic acid (hydracryclic acid). Ammonia gives the β-alanine, which is a commercial process.[5]
Propiolactone was once widely produced as an intermediate in the production of acrylic acid and its esters. That application has been largely displaced in favor of safer and less expensive alternatives. β-Propiolactone is an excellent sterilizing and sporicidal agent, but its carcinogenicity precludes that use.[2] It is used to inactivate a wide variety of viruses,[7] for example as a step in vaccine production.[8] The principal use of propiolactone is an intermediate in the synthesis of other chemical compounds.[5]
Safety
β-Propiolactone is "reasonably anticipated to be a human carcinogen" (IARC, 1999).[2] It is one of 13 "OSHA-regulated carcinogens," chemicals regarded occupational carcinogens by the U.S. Occupational Safety and Health Administration, despite not having an established permissible exposure limit.[9]
^ a b c"β-Propiolactone CAS No. 57-57-8" - US Department of Health and Human Services, Report on Carcinogens, National Toxicology Program, Thirteenth Edition, 2 October 2014. Accessed on 2015-01-03.
^Merck Index, 12th Edition, entry 8005.
^Miller, Raimund; Abaecherli, Claudio; Said, Adel; Jackson, Barry (2001). "Ketenes". Ullmann's Encyclopedia of Industrial Chemistry. doi:10.1002/14356007.a15_063. ISBN 978-3-527-30385-4.
^John W. Kramer; Daniel S. Treitler; Geoffrey W. Coates (2009). "Low Pressure Carbonylation of Epoxides to β-Lactones". Org. Synth. 86: 287. doi:10.15227/orgsyn.086.0287.
^Logrippo, Gerald A. (1960). "Investigations of the Use of Beta-Propiolactone in Virus Inactivation". Annals of the New York Academy of Sciences. 83 (4): 578–594. Bibcode:1960NYASA..83..578L. doi:10.1111/j.1749-6632.1960.tb40931.x. PMID 14417982. S2CID 6025589.