La sede del condado es West Chester.

Según el censo de 2000,[3]​ habían 433,501 personas, 157,905 hogares y 113,375 familias residiendo en la localidad.

El 89.21% de los habitantes eran blancos, el 6.24% afroamericanos, el 0.15% amerindios, el 1.95% asiáticos, el 0.03% isleños del Pacífico, el 1.35% de otras razas y el 1.06% pertenecía a dos o más razas.

Los hombres tenían unos ingresos medios en 2000 de $51,223 frente a los $34,854 para las mujeres.

Coatesville Atglen | Avondale | Downingtown | Elverson | Honey Brook | Kennett Square | Malvern | Modena | Oxford | Parkesburg | Phoenixville | South Coatesville | Spring City | West Chester | West Grove Birmingham | Caln | Charlestown | East Bradford | East Brandywine | East Caln | East Coventry | East Fallowfield | East Goshen | East Marlborough | East Nantmeal | East Nottingham | East Pikeland | East Vincent | East Whiteland | Easttown | Elk | Franklin | Highland | Honey Brook | Kennett | London Britain | London Grove | Londonderry | Lower Oxford | New Garden | New London | Newlin | North Coventry | Penn | Pennsbury | Pocopson | Sadsbury | Schuylkill | South Coventry | Thornbury | Tredyffrin | Upper Oxford | Upper Uwchlan | Uwchlan | Valley | Wallace | Warwick | West Bradford | West Brandywine | West Caln | West Fallowfield | West Goshen | West Marlborough | West Nantmeal | West Nottingham | West Pikeland | West Sadsbury | West Vincent | West Whiteland | Westtown | Willistown Berwyn | Caln | Chesterbrook | Cochranville | Devon | Devon-Berwyn (histórico) | Eagleview | Exton | Kenilworth | Lincoln University | Lionville | Lionville-Marchwood (histórico) | Paoli | South Pottstown | Thorndale | Toughkenamon | West Goshen | Westwood Birchrunville | Bucktown | Chester Springs | Cheyney | Cossart | Coventryville | Daylesford | Eagle | Embreeville | Ercildoun | Hopewell | Kemblesville | Kimberton | Knauertown | Landenberg | Lower Hopewell | Ludwigs Corner | Marshallton | Mortonville | Nottingham | Pughtown | Southeastern | Strafford | Strickersville | Sugartown | Unionville | Valley Forge | Wayne | West King of Prussia | Willowdale | Yellow Springs