The 2018 Duquesne Dukes football team represented Duquesne University in the 2018 NCAA Division I FCS football season. They were led by 14th-year head coach Jerry Schmitt and played their home games at Arthur J. Rooney Athletic Field. They played as a member of the Northeast Conference. They finished the season 9–4, 5–1 in NEC play to be NEC co-champions with Sacred Heart. Due to their head-to-head win over Sacred Heart, they received the NEC's automatic bid to the FCS Playoffs where they defeated Towson in the first round before losing in the second round to South Dakota State.
The NEC released their preseason coaches poll on July 24, 2018, with the Dukes predicted to finish in second place.[2]
The Dukes placed five players on the preseason all-NEC team.[3]