Lorenzo Sonego defeated defending champion Laslo Đere in the final, 2–6, 7–6(7–5), 6–4 to win the men's singles title at the 2021 Sardegna Open. With the victory, Sonego became the first Italian in 15 years to capture an ATP Tour title on home soil.[citation needed]
The top four seeds received a bye into the second round.
Dan Evans (second round)
Taylor Fritz (semifinals)
Lorenzo Sonego (champion)
Nikoloz Basilashvili (semifinals)
Jan-Lennard Struff (quarterfinals).svg/1280px-Flag_of_Australia_(converted).svg.png){kind=small}
John Millman (second round)
Guido Pella (first round) Tommy Paul (first round)