The Territorial Prelature of Santiago Apóstol de Huancané (Latin: Praelatura Territorialis Iacobus Apostolus Huancanensis) is a Roman Catholic territorial prelature located in the city of Huancané in the ecclesiastical province of Arequipa in Peru.
On 3 April 2019, the Territorial Prelature of Santiago Apóstol de Huancané was established from the Roman Catholic Territorial Prelature of Ayaviri and Roman Catholic Territorial Prelature of Juli.