Montignies-sur-Sambre (Walloon: Montgneye-so-Sambe) is a town of Wallonia and a district of the municipality of Charleroi, located in the province of Hainaut, Belgium.
It was a municipality of its own before the fusion of the Belgian municipalities in 1977.
Montignies hosts the UCLouvain Charleroi campus of the University of Louvain.