Margravine Sophie Christine Louise of Brandenburg-Bayreuth (in German: Sophie Christine Luise, Markgräfin von Brandenburg-Bayreuth; 4 January 1710 – 13 June 1739) was a member of the Brandenburg-Bayreuth line of the House of Hohenzollern and a Margravine of Brandenburg-Bayreuth by birth. Through her marriage to Alexander Ferdinand, 3rd Prince of Thurn and Taxis, Sophie Christine was also a member of the Princely House of Thurn and Taxis and Hereditary Princess of Thurn and Taxis.
Sophie Christine was the eldest child and daughter of George Frederick Charles, Margrave of Brandenburg-Bayreuth and his first wife Princess Dorothea of Schleswig-Holstein-Sonderburg-Beck.
Sophie Christine married Alexander Ferdinand, Hereditary Prince of Thurn and Taxis, the eldest child and only son of Anselm Franz, 2nd Prince of Thurn and Taxis and his wife Maria Ludovika Anna Franziska, Princess of Lobkowicz, on 11 April 1731 in Frankfurt am Main. Sophie Christine and Alexander Ferdinand had five children: