The Mandelin reagent is used as a simple spot-test to presumptively identify alkaloids as well as other compounds. It is composed of a mixture of ammonium metavanadate and concentrated sulfuric acid. Its primary use is for the detection of ketamine and PMA[1] Unlike the most common reagent test chemicals, it has a deep red colour that changes to yellow if there is no alkaloid, which occurs within about 48 hours of mixing.[2]
The United States Department of Justice method for producing the reagent is the addition of 100 mL of concentrated (95–98%) sulfuric acid to 0.5[3]-1 g of ammonium metavanadate.[4]
This reagent was invented by the German pharmacologist, Karl Friedrich Mandelin (1854–1906) at the University of Dorpat.
See also
References
- ^ a b c d "Mandelin EZ Testing Kit". EZ Test. Retrieved 2012-01-27.
- ^ "Reagent Tests UK - Mandelin reagent". Reagent Tests UK. Retrieved 3 April 2016.
- ^ Poe, Charles F.; O'Day, David W. (2006). "A study of Mandelin's test for strychnine". Journal of the American Pharmaceutical Association. 19 (12): 1292. doi:10.1002/jps.3080191206.
- ^ a b "Color Test Reagents/Kits for Preliminary Identification of Drugs of Abuse" (PDF). Law Enforcement and Corrections Standards and Testing Program. July 2000. Retrieved 2011-07-24.
- ^ "2-C-T-7 Mandelin". Reagent Base. 29 January 2015.
- ^ a b "Dancesafe Mandelin Reagent". Dancesafe. Retrieved 10 August 2015.
- ^ Mahmood, Zafar Alam (2013). "Bioactive Alkaloids from Fungi: Psilocybin". Natural Products: Phytochemistry, Botany and Metabolism of Alkaloids, Phenolics and Terpenes. Springer-Verlag. pp. 523–552. ISBN 978-3-642-22143-9.
