Petra Martić defeated Olga Danilović in the final, 6–4, 6–2 to win the singles tennis title at the 2022 Ladies Open Lausanne.[1][2] It was Martić's first WTA title since Istanbul in 2019.
Tamara Zidanšek was the defending champion, but was defeated in the first round by Anna Kalinskaya.[3]
Danielle Collins (first round).svg/1280px-Flag_of_Switzerland_(Pantone).svg.png){kind=small}
Belinda Bencic (quarterfinals)
Irina-Camelia Begu (second round)
Sara Sorribes Tormo (quarterfinals) Nuria Párrizas Díaz (first round)
Caroline Garcia (semifinals)
Tamara Zidanšek (first round)
Varvara Gracheva (first round) Katie Volynets (qualifying competition)
Olga Danilović (qualified) Anna Blinkova (qualified) Cristina Bucșa (qualified) Léolia Jeanjean (qualified).svg/1280px-Flag_of_Belgium_(civil).svg.png){kind=small}
Ysaline Bonaventure (withdrew) Anastasia Zakharova (qualifying competition) Erika Andreeva (qualified) Asia Muhammad (first round)
İpek Öz (qualifying competition) Elsa Jacquemot (first round) Alexandra Cadanțu-Ignatik (qualifying competition)