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Hobart Reimann

Hobart Ansteth Reimann (1897-1986) fue un virólogo y médico estadounidense . Reimann hizo contribuciones a la medicina con su histórico artículo de 1938 [3] sobre la neumonía atípica (la "primera descripción de la neumonía por virus" [4] ); y artículos sobre enfermedades periódicas [5] y el resfriado común (1948). [6] Participó activamente en las pruebas de estreptomicina contra la fiebre tifoidea, siendo "los primeros experimentos exitosos reportados públicamente". [7]

Desde 1935 hasta 1962, escribió la revisión anual de publicaciones importantes en el campo de las enfermedades infecciosas de la Revista de la Asociación Médica Estadounidense , que proporciona la sinopsis de los avances en el campo de la AMA . [8] Después de 1962, continuó este trabajo en Archives of Internal Medicine y en el British Post Graduate Medical Journal hasta 1975, "40 revisiones anuales consecutivas". [9]

Después de la Segunda Guerra Mundial, fue una de las primeras voces en hablar en contra del uso excesivo y mal uso de los antibióticos, [10] [11] [12] y testificó ante el Senado de los Estados Unidos sobre este tema a principios de la década de 1960.

Vida y carrera

Carrera temprana

On completing his training at the University of Buffalo Medical School, Reimann worked as first as resident and then as chief house physician at the Buffalo General Hospital. A stint as assistant physician at the Rockefeller Institute followed, working on the transformation of the pneumococcus from a rough strain to smooth and back again, under the direction of pioneering immunochemist Oswald Avery.

He spent a year at the Anton Ghon institute in Prague, as a specialist in infectious diseases, including Rocky Mountain spotted fever and tuberculous. After came two years in China as associate professor of medicine at the Beijing Union Medical College. He then returned to the United States, where the Great Depression was manifesting, taking a position at the University of Minnesota as associate professor of medicine. While at Minnesota, he wrote the first edition of his textbook, which became the four-volume series Treatment in General Medicine. He was offered the Magee Professorship and the position of chairman of the Department of Medicine, at the Jefferson Medical College in Philadelphia.[13]

Viral Pneumonia and Periodic Diseases (1936-51)

Reimann's interest in microorganisms developed further at Jefferson. "In a medical environment where empirical treatment and measures of dubious value were still common, Reimann insisted upon an etiological diagnosis whenever possible." He continued his work on the typing of the pneumococcus, establishing the practice of routine typing in patient cases where symptomatic pneumonia was displayed. This led to the publication of An Acute Infection of the Respiratory Tract with Atypical Pneumonia: a disease entity probably caused by a filtrable virus. (JAMA, 1938), an article of medical landmark status, being the first to describe viral, as opposed to bacterial, pneumonia.[14]

In 1945, he was involved in trials of streptomycin in the Philadelphia area, and was part of the trio of doctors who reported on its potential efficacy against paratyphoid fever.[15]

In 1948, Reimann published Periodic disease; a probable syndrome including periodic fever, benign paroxysmal peritonitis, cyclic neutropenia and intermittent arthralgia. This was one of the earliest accounts of periodic disease and fevers, later variously categorized as Periodic fever syndrome and Reimann syndrome (the latter of which, with Siegal-Cattan-Mamou disease, has been renamed as Familial Mediterranean fever).[13]

When Reimann came on to the staff at Jefferson, the medical staff consisted of 32 members. He expanded the department of medicine and began its residency program.[16] At the time of Reimann's resignation, there were 89 staff members, ten residents, and three fellows.[17]

Overseas appointments

From 1951, Reimann took on a decade of international appointments. He spent four years at the American University of Beirut in Lebanon as visiting professor of medicine. In return for his work for the nation, both in training medical staff and his ongoing work on infectious diseases, he was awarded the Order of the Cedar. A short interlude at the University of Indonesia, Djakarta, followed (funded by the UCLA Medicine in Indonesia project).[18] Then came three years in Shiraz, Iran (then Persia) at Mohammad Reza Pahlavi's behest, where he established a medical curriculum at the Shiraz Medical School patterned after the American model.[19]

Hahnemann Medical College

Reimann returned to the US as professor of medicine at Hahnemann Medical College in 1960, where he continued his research pursuits. He became involved in the movement against the over-prescription and misuse of antibiotics. In 1963, following publication on the same topic in the AMA, he was called before the US Senate to testify on antibiotic misuse. Reimann's conclusion was that most misuse was the result of bad doctoring, against which he believed there was little that could be effected. "Physicians often resent criticism and do not like to be told what not to do."[20]

Reimann's 1967 assignment in Saigon, Vietnam was funded by the AMA and AIG. They wanted him to reorganize the medical school at the University of Saigon.[16] Events of the Vietnam War intervened.

Later years and legacy

Reimann also did artwork. His "Pretzel Vendor" pastel featured as the JAMA cover in 1972.[21] He spent his final years traveling as guest lecturer. He died in 1986, from a fall followed by pneumonia.

His legacy is his students and the more than 300 papers[22] he published as diagnostic achievements during the period of medical work in that preceded the age of cellular and computational study.

Honors and awards

Career postings

Selected publications

Books

References

  1. ^ Reimann, Hobart A., Periodic Disease: Observations on Old Cases and Report of New Cases and of Therapeutic Trials. JAMA. 1953;92(4):494–506. doi:10.1001/archinte.1953.00240220042009
  2. ^ Reimann, Hobart A., Infectious Diseases: Twentieth Annual Review of Significant Publications. JAMA Arch Intern Med. 1955;96(1):90–125. doi:10.1001/archinte.1962.03620130062010
  3. ^ a b Landmark article Dec 24,1938: Reimann, Hobart A., An acute infection of the respiratory tract with atypical pneumonia. A disease entity probably caused by a filtrable virus. National Center for Biotechnology Information, 1984. DOI:10.1001/jama.1938.02790520033007
  4. ^ John H, Hodges MD (1989). Wagner, MD, Frederick B (ed.). "Thomas Jefferson University: Tradition and Heritage". Jefferson Digital Commons. Part III, Chapter 9: Department of Medicine. p. 253.
  5. ^ a b Reimann, Hobart A (1948). "Periodic Disease: a probable syndrome including periodic fever, benign paroxysmal peritonitis, cyclic neutropenia and intermittent arthralgia". JAMA. 136 (4): 239–244. doi:10.1001/jama.1948.02890210023004. PMID 18920089.
  6. ^ "COMMON COLD REMEDIES". Horsham Times (Vic. : 1882 - 1954). 1948-01-16. p. 2. Retrieved 2020-04-18.
  7. ^ "New Drug is used to treat Typhoid; Streptomycin Found Effective Against Disease for Which No Cure Was Known". New York Times. May 24, 1945. Retrieved 2020-3-26
  8. ^ Reimann, Hobart A., Infectious Diseases: Annual Review of Significant Publications,(1943-1962) JAMA. Retrieved 2020-3-26
  9. ^ John H, Hodges MD (1989). Wagner, MD, Frederick B (ed.). "Thomas Jefferson University: Tradition and Heritage". Jefferson Digital Commons. Part III, Chapter 9: Department of Medicine. pp. 253–254.
  10. ^ John, Joseph F. Jr.; Fishman, Neil O. (1997). "Programmatic Role of the Infectious Diseases Physician in Controlling Antimicrobial Costs in the Hospital". Clinical Infectious Diseases. 24 (3). Oxford University Press: 471–85. doi:10.1093/clinids/24.3.471. JSTOR 4481020. PMID 9114203.
  11. ^ Most Penicillin Held Wasted, The New York Times (Jan 26, 1951), Retrieved 2020-3-26.
  12. ^ Osmundsen, John A.,PNEUMONIA DEFIES ANTIBIOTIC DRUGS; A.M.A. Is Told Widespread Use of Preparations Has Created New Problems, The New York Times (Jul 01, 1961), Retrieved 2020-3-26.
  13. ^ a b Hodges, Dr. John, Department of Medicine, Clinical Departments and Divisions, Thomas Jefferson University Jefferson Digital Commons, (1989), JOHN H. HODGES, M.D.
  14. ^ John H, Hodges MD (1989). Wagner, MD, Frederick B (ed.). "Thomas Jefferson University: Tradition and Heritage". Jefferson Digital Commons. Part III, Chapter 9: Department of Medicine. p. 253.
  15. ^ Science Digest. Science Digest, Incorporated. 1945–1947.
  16. ^ a b "Hobart Reimann, Medical Professor". Philadelphia, PA: The Philadelphia Inquirer. January 20, 1986.
  17. ^ John H, Hodges MD (1989). Wagner, MD, Frederick B (ed.). "Thomas Jefferson University: Tradition and Heritage". Jefferson Digital Commons. Part III, Chapter 9: Department of Medicine. p. 257.
  18. ^ John H, Hodges MD (1989). Wagner, MD, Frederick B (ed.). "Thomas Jefferson University: Tradition and Heritage". Jefferson Digital Commons. Part III, Chapter 9: Department of Medicine. p. 255.
  19. ^ Rothkopf, Michael M.; Nusbaum, Michael J.; Haverstick, RDN, CNSC, Lisa P. (2014-11-07). Metabolic Medicine and Surgery. CRC Press. p. 579. ISBN 978-1-4665-6712-2.{{cite book}}: CS1 maint: multiple names: authors list (link)
  20. ^ Operations, United States Congress Senate Committee on Government (1963). Exhibit 178: Antibiotics: Summary of Dr. Hobart A. Reimann's comments prior to his testimony, as published in JAMA, and subsequent editorial on use and misuse of antibiotics as printed in the same journal. U.S. Government Printing Office. pp. 1305–07. Interagency Coordination in Drug Research and Regulation: Hearings Before the Subcommittee on Reorganization and International Organizations of the Committee on Government Operations, United States Senate, Eighty-eighth Congress, First Session. Agency Coordination Study, Pursuant to S. Res. 27, 88th Cong. Review of Cooperation on Drug Policies Among Food and Drug Administration, National Institutes of Health, Veterans' Administration, and Other Agencies. Mar. 20-June 26, 1963
  21. ^ "Drexel University, College of Medicine, Archives & Special Collections: Collection Descriptions, Accessions #1 - 20". archives.drexelmed.edu. Retrieved 2020-04-17.
  22. ^ John H, Hodges MD (1989). Wagner, MD, Frederick B (ed.). "Thomas Jefferson University: Tradition and Heritage". Jefferson Digital Commons. Part III, Chapter 9: Department of Medicine. p. 252.
  23. ^ Operations, United States Congress Senate Committee on Government (1963). Exhibit 177: Summary of Professional Career of Hobart A. Reimann, MD. U.S. Government Printing Office. pp. 1295–97language=en. Interagency Coordination in Drug Research and Regulation: Hearings Before the Subcommittee on Reorganization and International Organizations of the Committee on Government Operations, United States Senate, Eighty-eighth Congress, First Session. Agency Coordination Study, Pursuant to S. Res. 27, 88th Cong. Review of Cooperation on Drug Policies Among Food and Drug Administration, National Institutes of Health, Veterans' Administration, and Other Agencies. Mar. 20-June 26, 1963
  24. ^ Reimann, Hobart A (1938). "An Acute Infection of the Respiratory Tract with Atypical Pneumonia: a disease entity probably caused by a filtrable virus". JAMA. 111 (26): 2377–2384. doi:10.1001/jama.1938.02790520033007.
  25. ^ Reimann, Hobart A (1949). "Periodic Disease: periodic fever, periodic abdominalgia, cyclic neutropenia, intermittent arthralgia, angioneurotic edema, anaphylactoid purpura and periodic paralysis". JAMA. 141 (3): 175–183. doi:10.1001/jama.1949.02910030005002. PMID 18139542.
  26. ^ Reimann, Hobart A (1975). "Infectious Diseases: fortieth and final annual review of significant publications". Postgraduate Medical Journal. 51 (599): 600–610. doi:10.1136/pgmj.51.599.600. PMC 2496191. PMID 172878.