The 2005–06 KNVB Cup was the 88th edition of the premier knockout tournament in the Netherlands. The tournament started on 2 August 2005 and the final was held on 7 May 2006. Ajax beat PSV 2–1 in the final, winning the trophy for the sixteenth time.
E Eredivisie; 1 Eerste Divisie; A Amateur teams
Six Eredivisie teams entered the tournament this round. They had previously been playing in the Champions League and UEFA Cup.
E six Eredivisie entrants
Both Ajax and PSV already secured a Champions League spot in the national competition. Therefore, the UEFA Cup ticket the winner of this tournament would win, could now be won in the Eredivisie play-offs.