Born in Rio de Janeiro, Brena finished her formation with Vasco da Gama, making her senior debut with the club against Kindermann on 18 September 2014.[3]
Flamengo
She moved to Flamengo in the following year, making her debut against Centro Olímpico on 23 September 2015.[4]
Centro Olímpico
Brena represented Centro Olímpico in the 2016 season, scoring on her debut against América Mineiro on 21 January 2016, scoring in the 82nd minute.[5]
Santos
On 12 January 2017, Brena signed for Santos.[6] She made her league debut against Foz Cataratas on 13 March 2017.[7] Brena scored her first league goal for the club against São José on 25 April 2017, scoring in the 28th minute.[8]
Avaldsnes
On 11 December of the following year, after being the top goalscorer of the 2018 Copa Libertadores Femenina, she moved abroad with Avaldsnes IL.[9] Brena made her league debut for the club against Klepp on 23 March 2019.[10] She scored her first goal against Stabaek on 11 May 2019, scoring in the 46th minute.[11]
Return to Santos
Brena returned to Peixe in 2020. During her second spell at the club, she made her league debut against Flamengo on 8 February 2020.[12] Brena scored her first goal for the club against Cruzeiro on 17 February 2020, scoring in the 65th minute.[13] She was sidelined in April due to a knee injury.[14] Upon returning, she was a regular starter and captain before leaving in December 2023.[15]
Palmeiras
On 8 January 2024, Brena was announced at Palmeiras.[16] She made her league debut for the club against Flamengo on 16 March 2024.[17]
^ a b c d"Brena". Santos FC (in Brazilian Portuguese). Retrieved 2 May 2021.
^"Vasco da Gama vs Kindermann Avaí - 18 September 2014". int.soccerway.com.
^"Flamengo vs Centro Olímpico - 23 September 2015". int.soccerway.com.
^"Centro Olímpico vs América Mineiro - 21 January 2016". int.soccerway.com.
^"Santos reforça o time feminino com três novas jogadoras; conheça" [Santos bolster the women's team with three new players; know them] (in Brazilian Portuguese). GloboEsporte.com. 12 January 2017. Retrieved 3 May 2021.
^"Santos vs Foz Cataratas - 13 March 2017". int.soccerway.com.
^"Santos vs São José - 25 April 2017". int.soccerway.com.
^"Vi ønsker 2 nye spillere velkommen til Avaldsnes!" [We welcome 2 new players to Avaldsnes!] (in Norwegian). Avaldsnes IL. 11 December 2018. Retrieved 3 May 2021.
^"Klepp vs Avaldsnes - 23 March 2019". int.soccerway.com.
^"Avaldsnes vs Stabaek - 11 May 2019". int.soccerway.com.
^"Santos vs Flamengo - 8 February 2020". int.soccerway.com.
^"Santos vs Cruzeiro - 17 February 2020". int.soccerway.com.
^"Neymar deseja força para Brena, do Santos, após lesão no joelho" [Neymar wishes strength for Brena, from Santos, after knee injury] (in Brazilian Portuguese). Gazeta Esportiva. 29 April 2020. Retrieved 3 May 2021.
^"Capitã, Brena se despede das Sereias da Vila e cobra melhorias por futuro do time" [Captain, Brena bids farewell from the Sereias da Vila and demands improvements for the future of the team] (in Brazilian Portuguese). Diário do Peixe. 15 December 2023. Retrieved 4 January 2024.
^"Destaque em 2023, Palmeiras contrata meio-campista Brena Carolina para o time feminino" [Spotlight in 2023, Palmeiras sign midfielder Brena Carolina for the women's team] (in Brazilian Portuguese). SE Palmeiras. 8 January 2024. Retrieved 9 January 2024.
^"Palmeiras vs Flamengo - 16 March 2024". int.soccerway.com.
^"Papua New Guinea U20 vs Brazil U20 - 13 November 2016". int.soccerway.com.
^"Brena, Sereia da Vila, é convocada para amistoso da Seleção Brasileira Feminina" [Brena, Sereia da Vila, is called up to friendly of the Brazil women's national team] (in Brazilian Portuguese). Santos FC. 24 March 2017. Retrieved 3 May 2021.