The 2000–01 Israel State Cup (Hebrew: גביע המדינה, Gvia HaMedina) was the 62nd season of Israel's nationwide football cup competition and the 47th after the Israeli Declaration of Independence.
The competition was won by Maccabi Tel Aviv who had beaten Maccabi Petah Tikva 3–0 in the final.
By winning, Maccabi Tel Aviv qualified to the 2001–02 UEFA Cup, entering in the qualifying round.
Byes: Hapoel Majd al-Krum, Ironi Ofakim, Maccabi Isfiya, Maccabi Tur'an.