1-Hydroxy-7-azabenzotriazole

Chemical compound

1-Hydroxy-7-azabenzotriazole (HOAt) is a triazole used as a peptide coupling reagent.^[2] It suppresses racemization that can otherwise occur during the reaction.^[3]

HOAt has a melting point between 213 and 216 degrees Celsius.^[4] As a liquid, it is transparent and without any color.

References

1. GHS: Sigma Aldrich 445452
2. Carpino, Louis A (1993). "1-Hydroxy-7-azabenzotriazole. An efficient peptide coupling additive". Journal of the American Chemical Society. 115 (10): 4397–4398. doi:10.1021/ja00063a082.
3. Valeur, Eric; Bradley, Mark (2009). "Amide bond formation: beyond the myth of coupling reagents". Chemical Society Reviews. 38 (2): 606–631. doi:10.1039/b701677h. PMID 19169468.
4. "HOAt". Chemical Book. Retrieved January 30, 2019.